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In-vitro Anti-thrombosis Activity of R4-Nuruk Made from Rhizopus oryzae KSD-815
In-vitro Anti-thrombosis Activity of R4-Nuruk Made from Rhizopus oryzae KSD-815
Microbiology and Biotechnology Letters. 2015. Jun, 43(2): 169-174
Copyright © 2015, The Korean Society for Microbiology and Biotechnology
  • Received : February 12, 2015
  • Accepted : March 25, 2015
  • Published : June 28, 2015
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About the Authors
미선 김
예슬 이
종식 김
우창 신
호용 손
hysohn@anu.ac.kr

Abstract
누룩은 전 세계적으로도 독특한 우리만의 발효제로, 전분 당화 및 발효미생물의 접종원으로 이용된다. Rhizopus oryzae KSD-815로 제조된 개량누룩(R4로 명명)은 발효제 특성 이외에 암세포 생육억제, 항비만 활성 등이 알려져 있다. 본 연구에서는 R4 누룩의 열수 및 ethanol 추출물과 이들의 순차적 유기용매 분획물을 조제하여 항혈전 활성을 평가한 결과, ethylacetate 분획에서 우수한 항응고 활성을 확인하였으며, 열수 추출물의 ethylacetate 및 butanol 분획은 인간 적혈구 용혈활성을 나타내지 않으면서 혈소판 응집저해 활성을 나타내었다. 본 연구결과는 R4 누룩이 항응고 및 혈소판 응집저해 개발의 유용자원으로 이용 가능함을 제시하고 있다.
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Acknowledgements
This research was supported by High Value-added Food Technology Development Program (No. 112073-3), Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea.
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