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Red Ginseng Ethanol Extract Suppressed Ag I/II-induced Up-expression of Inflammatory Mediators in RAW 264.7 Macrophages
Red Ginseng Ethanol Extract Suppressed Ag I/II-induced Up-expression of Inflammatory Mediators in RAW 264.7 Macrophages
Microbiology and Biotechnology Letters. 2015. Jun, 43(2): 158-163
Copyright © 2015, The Korean Society for Microbiology and Biotechnology
  • Received : February 04, 2015
  • Accepted : June 01, 2015
  • Published : June 28, 2015
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About the Authors
경민 최
승미 황
지예 임
은실 고
종혁 박
정혜 문
민정 이
지은 장
정단 차
joungdan@ijrg.re.kr

Abstract
본 연구에서, 우리는 S. mutans Ag I/II 재조합단백질에 의해 유도되어진 염증유발 단백질의 발현에 홍삼 40% 에탄올 추출물의 효과를 알아보고자 하였다. 홍삼에탄올추출물은 Ag I/II 재조합단백질에 의해 유도되어진 염증유발물질들의 mRNA와 단백질의 발현을 억제하였다. 더불어 홍삼에탄올 추출물은 NF-κΒ p65가 핵내로 이용하는 것이 억제하였다. 결론적으로 홍삼 40%에탄올추출물은 NF-κB의 활성에 의해 NO 생성과 iNOS 발현이 조절되어지는 것으로 생각되어지며, 염증유발 관련 유전자들의 낮은 발현을 유도하는 것으로 관찰되어졌다.
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Acknowledgements
This research was supported by the Ministry of Knowledge Economy (MKE-R0002038).
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