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Effect of Ionic Liquid on Increased Surface Area Crystallization Process for Vancomycin
Effect of Ionic Liquid on Increased Surface Area Crystallization Process for Vancomycin
Microbiology and Biotechnology Letters. 2014. Jul, 42(3): 297-301
Copyright © 2014, The Korean Society for Microbiology and Biotechnology
  • Received : July 14, 2014
  • Accepted : August 20, 2014
  • Published : July 30, 2014
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성재 김
진현 김
jinhyun@kongju.ac.kr

Abstract
본 연구에서는 실리카겔을 이용한 반응액 부피당 표면적(surface area per volume of reaction solution)이 증가된 반코마이신 결정화 공정에서 이온성 액체의 영향을 조사하였다. 실리카겔로 표면적을 증가시킨 경우에 이온성 액체([BMIm][BF 4 ])를 접목하면 결정화 효율을 더욱 향상시킬 수 있었다. 실리카겔을 이용한 표면적이 증가된 결정화에서 이온성 액체(20%, v/v)를 첨가한 경우 결정화 4시간에 반코마이신 결정이 생성되었으며 실리카겔과 이온성 액체를 사용하지 않은 경우보다 결정화에 소요되는 시간을 6배 정도 단축시킬 수 있었다. 또한 이온성 액체 첨가량이 증가함에 따라 반코마이신 결정 입자크기가 감소할 뿐만 아니라 결정이 균일하고 일정해짐을 알 수 있었다.
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References
Griffith RS 1984 Vancomycin use-an historical review J. Antimicrob. Chemother. 14 1 - 5
Hebel D , Ürdingen M , Hekmat D , Weuster-Botz D 2013 Development and scale up of high-yield crystallization processes of lysozyme and lipase using additives Cryst. Growth Des. 13 2499 - 2506    DOI : 10.1021/cg400212p
Judge RA , Takahashi S , Longenecker KL , Fry EH , Abad-Zapatero C , Chi ML 2009 The effect of ionic liquids on protein crystallization and X-ray diffraction resolution Cryst. Growth Des. 9 3463 - 3469    DOI : 10.1021/cg900140b
Kim KJ 2001 Crystallization process and technology Prospect. Ind. Chem. 4 1 - 15
Kim SI , Han CY , Jung HS , Lee JS , Ok SY , Kim SC 2006 Effects of vancomycin on the neuromuscular blockade of vecuronium, rocuronium and atracurium in rat phrenic nervehemidiaphragm preparation Korean J. Anesthesiol. 51 727 - 732
Kim WS , Lee EK 2005 Technological trend of crystallization research for bioproduct separation Korean J. Biotechnol. Bioeng. 20 164 - 176
Kim YN , Lee JY , Kim JH 2011 Improvement of a crystallization process for the purification of vancomycin Process Biochem. 46 2068 - 2073    DOI : 10.1016/j.procbio.2011.07.020
Kroon MC , Toussaint VA , Shariati A , Florusse L , Spronsen JV , Witkamp GJ 2008 Crystallization of an organic compound from an ionic liquid using carbon dioxide as antisolvent Green Chem. 10 333 - 336    DOI : 10.1039/b712848g
Kwak EA , Kim SJ , Kim JH 2012 Effect of ion exchange resin on increased surface area crystallization process for purification of vancomycin Korean J. Chem. Eng. 29 1487 - 1492    DOI : 10.1007/s11814-012-0135-8
Lee JW , Jung YT , Suh JW , Lee KS 2006 Process of purifying vancomycin hydrochloride
Lee JY , Lee KH , Chae HJ , Kim JH 2010 Systematic evaluation and optimization of crystallization conditions for vancomycin purification Korean J. Chem. Eng. 27 1538 - 1546    DOI : 10.1007/s11814-010-0242-3
Li XX , Xu XD , Dan YY , Feng J , Ge L , Zhang ML 2008 The crystallization of lysozyme in the system of ionic liquid [BMIm][BF4]-water Crystallogr. Rep. 43 1062 - 1068
Li XX , Xu XD , Dan YY , Zhang ML 2009 The Crystallization of lysozyme and thaumatin with ionic liquid Crystallogr. Rep. 54 1285 - 1288    DOI : 10.1134/S1063774509070268
Pusey ML , Paley MS , Turner MB , Rogers RD 2007 Protein crystallization using room temperature ionic liquids Cryst. Growth Des. 7 787 - 793    DOI : 10.1021/cg060696t
2006 United States Pharmacopoeia (USP 29): Vancomycin hydrochloride United State Pharmacopeial Convention, Inc.
Wang Z , Fang W , Li Y , Zhang J , Gu Q 2014 A new strategy for protein crystallization: Effect of ionic liquids on lysozyme crystallization and morphology Korean J. Chem. Eng. 31 919 - 923    DOI : 10.1007/s11814-014-0057-8
Yan H , Qi D , Cheng X , Song Z , Li W , He B 1998 Antibiotic activities and affinities for bacterial cell wall analogue of N-demethylvancomycin and its derivatives J. Antibiot. 51 750 - 756    DOI : 10.7164/antibiotics.51.750