Antiviral Activity of Gallic Acid against Coxsackievirus B3 and Coxsackievirus B4
Antiviral Activity of Gallic Acid against Coxsackievirus B3 and Coxsackievirus B4
Microbiology and Biotechnology Letters. 2014. Jun, 42(2): 207-210
Copyright © 2014, The Korean Society for Microbiology and Biotechnology
  • Received : April 16, 2014
  • Accepted : May 12, 2014
  • Published : June 28, 2014
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화정, 최

Viral infections are capable of inducing reactive oxygen species (ROS) production in the infected cells and antioxidants have been reported to have antiviral activities against many viruses. In this study, an antiviral assay using the cytopathic effect (CPE) reduction method revealed that gallic acid possesses good anti-coxsackievirus B3 (CB3) and coxsackievirus B4 (CB4) activities, reducing the formation of visible CPE. However, ribavirin did exhibit weak anti-CB3 and CB4 activities and was unable to prevent CPE. Therefore, we conclude that the inhibition of CB3 or CB4 production by gallic acid may be due to its general action as an antioxidant.
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This research was supported by Kwangju Women's University in 2014, Korea.
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