Advanced
Antiviral Activity of Gallic Acid against Coxsackievirus B3 and Coxsackievirus B4
Antiviral Activity of Gallic Acid against Coxsackievirus B3 and Coxsackievirus B4
Microbiology and Biotechnology Letters. 2014. Apr, 42(2): 207-210
Copyright © 2014, The Korean Society for Microbiology and Biotechnology
  • Received : April 16, 2014
  • Accepted : May 12, 2014
  • Published : April 28, 0214
Download
PDF
e-PUB
PubReader
PPT
Export by style
Share
Article
Author
Metrics
Cited by
TagCloud
About the Authors
화정 최
rerived@kwu.ac.kr

Abstract
Viral infections are capable of inducing reactive oxygen species (ROS) production in the infected cells and antioxidants have been reported to have antiviral activities against many viruses. In this study, an antiviral assay using the cytopathic effect (CPE) reduction method revealed that gallic acid possesses good anti-coxsackievirus B3 (CB3) and coxsackievirus B4 (CB4) activities, reducing the formation of visible CPE. However, ribavirin did exhibit weak anti-CB3 and CB4 activities and was unable to prevent CPE. Therefore, we conclude that the inhibition of CB3 or CB4 production by gallic acid may be due to its general action as an antioxidant.
Keywords
PPT Slide
Lager Image
PPT Slide
Lager Image
Acknowledgements
This research was supported by Kwangju Women's University in 2014, Korea.
References
Agol VI , Belov GA , Bienz K , Egger D , Kolesnikova MS , Raikhlin NT , et al. 1998 Two types of death of poliovirus-infected cells: caspase involvement in the apoptosis but not cytopathic effect Virol et al. 252 343 - 353    DOI : 10.1006/viro.1998.9438
Bhatt LR , Yook CN , Choi HJ , Baek SH 2008 Radical scavenging activity of gallic acid from Woodfordia Fruticosa flowers Korean J. Oriental Physiol. Pathol. 22 903 - 906
Choi HJ , Kim JH , Lee CH , Ahn YJ , Song JH , Baek SH , et al. 2008 Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus Antiviral Res. et al. 81 77 - 81
Gaudernak E , Seipelt J , Triendl A , Grassauer A , Kuechler E 2002 Antiviral effects of pyrrolidine dithiocarbamate on human rhinoviruses J. Virol. 76 6004 - 6015    DOI : 10.1128/JVI.76.12.6004-6015.2002
Jason DG , Craig EC 2006 Mechanisms of action of ribavirin against distinct viruses Rev. Med. Virol. 16 37 - 48    DOI : 10.1002/rmv.483
Kaul P , Biagioli MC , Singh I , Turner RB 2000 Rhinovirus induced oxidative stress and interleukin-8 elaboration involves p47-phox but is independent of attachment to intercellular adhesion molecule-1 and viral replication J. Infect. Dis. 181 1885 - 1890    DOI : 10.1086/315504
Kratz JM , Andrighetti-Fröhner CR , Kolling DJ , Leal PC , Cirne-Santos CC , Yunes RA , et al. 2008 Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate Mem. Inst. Oswaldo Cruz et al. 103 437 - 442    DOI : 10.1590/S0074-02762008000500005
Weiss L , Hildt E , Hofschneider PH 1996 Anti-hepatitis B virus activity of N-acetyl-L-cysteine (NAC): new aspects of a wellestablished drug Antiviral Res 32 43 - 53    DOI : 10.1016/0166-3542(95)00977-9