Advanced
Antibacterial Activity Evaluation of Radioisotope Lu-177 with a Modified Tube on Plate Core
Antibacterial Activity Evaluation of Radioisotope Lu-177 with a Modified Tube on Plate Core
Microbiology and Biotechnology Letters. 2013. Oct, 41(4): 469-471
Copyright © 2013, The Korean Society for Microbiology and Biotechnology
  • Received : November 13, 2013
  • Accepted : December 05, 2013
  • Published : October 28, 2013
Download
PDF
e-PUB
PubReader
PPT
Export by style
Share
Article
Author
Metrics
Cited by
TagCloud
About the Authors
은하 조
Choeh36@kaeri.re.kr

Abstract
본 연구를 통하여 우리는 새로운 실험기구를 사용하여 방사성동위원소(Lu-177)의 항균능력을 측정하였다. 기존에 약물의 항균능력을 측정하는데 사용되었던 디스크법은 배지로의 약물 확산에 의해서 항균능력을 측정하는 방법이기 때문에 방사성동위원소에 적용하기는 적합하지 않아 새로운 실험 방법이 요구된다. 방사성동위원소의 항균능력을 측정하기 위해서는 배지로의 약물 확산을 막고 한점에 머무르게 하는 방법이 필요하다. 본 연구에서 우리는 새로운 실험도구를 이용하여 Lu-177의 방사능량이 증가할수록 항균능력이 증가함을 확인하였다. 본 연구에서 사용된 실험방법을 통해 다른 방사성동위원소의 항균능력도 쉽게 측정할 수 있을 것으로 기대된다.
Keywords
PPT Slide
Lager Image
PPT Slide
Lager Image
References
Abedi D , Feizizadeh S , Akbari V , Jafarian-Dehkordi A 2013 In vitro anti-bacterial and anti-adherence effects of Lactobacillus delbrueckii subsp bulgaricus on Escherichia coli Res. Pharm. Sci. 8 260 - 268
Bryan RA , Guimaraes AJ , Hopcraft S , Jiang Z , Bonilla K , Morgenstern A , et al. 2012 Toward developing a universal treatment for fungal disease using radioimmunotherapy targeting common fungal antigens Mycopathologia et al. 173 463 - 471    DOI : 10.1007/s11046-011-9476-9
De Guzman ZM , Cervancia CR , Dimasuay KG , Tolentino MM , Abrera GB , Cobar ML , et al. 2011 Radiation inactivation of Paenibacillus larvae and sterilization of American Foul Brood (AFB) infected hives using Co-60 gamma rays Appl. Radiat. Isot. et al. 69 1374 - 1379    DOI : 10.1016/j.apradiso.2011.05.032
Huclier-Markai S , Alliot C , Varmenot N , Cutler CS , Barbet J 2012 Alpha-emitters for immuno-therapy: a review of recent developments from chemistry to clinics Curr. Top. Med. Chem 12 2642 - 2654
Hueting R , Tavaré R , Dilworth JR , Mullen GE 2013 Copper- 64 radiolabelling of the C2A domain of synaptotagmin I using a functionalised bis(thiosemicarbazone): A pre- and postlabelling comparison J. Inorg. Biochem. 128 108 - 111    DOI : 10.1016/j.jinorgbio.2013.07.017
Jeon YH , Lee HW , Lee YL , Kim JE , Hwang MH , Jeong SY , et al. 2011 Combined E7-dendritic cell-based immunotherapy and human sodium/iodide symporter radioiodine gene therapy with monitoring of antitumor effects by bioluminescent imaging in a mouse model of uterine cervical cancer Cancer. Biother. Radiopharm et al. 26 671 - 679    DOI : 10.1089/cbr.2011.1081
Kang CS , Sun X , Jia F , Song HA , Chen Y , Lewis M , et al. 2012 Synthesis and preclinical evaluation of bifunctional ligands for improved chelation chemistry of 90Y and 177Lu for targeted radioimmunotherapy Bioconjug. Chem. et al. 23 1775 - 1782    DOI : 10.1021/bc200696b
Otani Y , Yamada T , Kato S , Shikama N , Funakoshi K , Kuroda I , et al. 2013 Source strength assay of iodine-125 seeds sealed within sterile packaging J. Appl. Clin. Med. Phys. et al. 14 4082 -
Somily AM 2010 Comparison of E-test and disc diffusion methods for the in vitro evaluation of the antimicrobial activity of colistin in multi-drug resistant Gram-negative Bacilli Saudi. Med. J. 31 507 - 511
Towers S 2013 Improving the control of systematic uncertainties in precision measurements of radionuclide half-life Appl. Radiat. Isot. 77 110 - 114    DOI : 10.1016/j.apradiso.2013.03.003
Ujjani C , Cheson BD 2013 The current status and future impact of targeted therapies in non-Hodgkin lymphoma Expert. Rev. Hematol. 6 191 - 202    DOI : 10.1586/ehm.13.6
Vera DR , Eigner S , Henke KE , Lebeda O , Melichar F , Beran M 2012 Preparation and preclinical evaluation of 177Lu-nimotuzumab targeting epidermal growth factor receptor overexpressing tumors Nucl. Med. Biol. 39 3 - 13    DOI : 10.1016/j.nucmedbio.2011.07.001
Yong KJ , Milenic DE , Baidoo KE , Brechbiel MW 2013 Sensitization of tumor to 212Pb radioimmunotherapy by gemcitabine involves initial abrogation of G2 arrest and blocked DNA damage repair by interference with Rad51 Int. J. Radiat. Oncol. Biol. Phys. 85 1119 - 1126    DOI : 10.1016/j.ijrobp.2012.09.015