A new series of novel 2-morpholino- N -(4,6-diarylpyrimidin-2-yl)acetamides 34 - 42 is synthesized by the condensation of 2-chloro- N -(4,6-diarylpyrimidin-2-yl)acetamides 25 - 33 with morpholine in the presence of anhydrous potassium carbonate. The synthesized compounds have been characterized by melting point, elemental analysis, MS, FT-IR, one-dimensional NMR ( ¹ H & ¹³ C) spectroscopic data. Pyrimidines being an integral part of nucleic acids and many chemotherapeutic agents display a wide range of pharmacological activities as bactericide, 1 fungicide, 2 phosphodiesterase inhibitor, 3 viricide, 4 and leishmancide. 5 Pyrimidines are the basic nucleus in nucleic acids and have been associated with a number of biological activities. 6 Substituted aminopyrimidine nuclei are common in marketed drugs such as anti-atherosclerotic aronixil, anti-histaminic thonzylamine, anti-anxielytic buspirone, anti-psoriatic enazadrem, and other medicinally relevant compounds. 7 Many pyrimidine derivatives have been found to be active against different forms of cancer. 8 Various method of synthesis and reactions of aminopyrimidines are reported. 9 - 11 Amides are well known for their therapeutic values. 12 The chemistry of chloro acetyl group has received significant attention through the years resulting in substantial advances both in the synthetic and medicinal aspects. N-Benzyl-β-chloropropionamide is a well-proven anticonvulsant agent 13 and is marketed under the trade name Hibicon and Hydrane. Chloroacetyl derivatives of some amines were found to exert diverse biological properties such as antiepileptic, 14 antiplasmodic, 15 antitumour, anti-MDR, 16 antimicrobial, 17 herbicidal, 18 mild stimulant and depressant activities. 19 Antibiotics like penicillins and cephalosporins have amide group. Novel bioactive natural compounds 20 are synthesized by the conversion of ketones into amides, since amide group is an important pharmacophores. Many N-fuctionalized morpholines have found to posses diverse pharmacological activites. They are reported to exert a number of important physiological activities such as antidiabetic, 21 , 22 antiemetic, 23 , 24 platelet aggregation inhibitors and antihyperlipo-proteinemics, 21 bronchodilators and growth stimulants 25 and antidepressants. 26 These were also used in the treatment of inflammatory diseases, pain, migraine and asthma. 24 Recently, we exploited the synthesis of some novel structurally diverse heterocyclic compounds comprising pyrimidine nucleus such as 3,4-dihydropyrimidin-2(1 H )-ones 27 and - thiones and 2-phenyl-3-(4,6-diarylpyrimidin-2-yl)thiazolidin-4-ones, 28 morpholine nucleus namely (E)-1-4-morpholinophenyl)-3-aryl-prop-2-en-1-ones 29 and amide moiety such as 2,7-diaryl-[1,4]-diazepan-5-ones. 30 In the interest of above, we planned to synthesize a target molecule, 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides which unite biolabile 4,6-diarylpyrimidin-2-amines, chloroacetyl chloride and morpholine moieties together to furnish a new series of compounds. A four-step synthetic route furnished the target compounds 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides 34 - 42 in good yields. A general schematic representation is given in 1 . The Claisen-Schmidt 31 condensation of equimolar quantities of appropriate acetophenone and appropriate benzaldehyde in the presence of sodium hydroxide gives E -1,3-diarylprop-2-en-1-ones 7 - 15 . When E -1,3-diarylprop-2-en-1-ones 7 - 15 are refluxed with guanidine nitrate in the presence of sodium hydroxide, 2-amino-4,6-diarylpyrimidines 32 16 - 24 are formed. Various substituted 2-chloro-N-(4,6-diarylpyridiarylpyrimidin-2-yl)acetamides 33 25 - 33 are synthesized by electrophilic substitution reaction of chloroacetyl chloride with the corresponding parent 2-amino-4,6-diarylpyrimidines 16 - 24 in the presence of triethyl amine as base and toluene as solvent. Then, condensation of 2-chloro-N-(4,6-diarylpyrimidin-2-yl)acetamides 25 - 33 with morpholine in the presence of anhydrous potassium carbonate furnished 2-morpholino-N-(4,6-diarylpyrimidin- 2-yl)acetamides 34 - 42 . The physical and analytical data for compounds 34 - 42 is given in 1 . The following nine compounds 34 - 42 are synthesized from the corresponding 2-chloro-N-(4,6-diarylpyrimidin-2-yl)acetamides 25 - 33 : The structures of all the newly synthesized compounds are characterized by m.p.’s, elemental analysis, FT-IR, MS, onedimensional NMR ( ¹ H and ¹³ C) spectra. FT-IR spectrum of 2-morpholino-N-(4,6-diphenylpyrimidin-yl)acetamide 34 shows characteristic absorption frequency ( 2 ) observed at 3314cm ^-1 is due to N-H stretching vibrations of the amide group. The absorption frequency at 3193 ~3030 cm ^-1 is assigned to aromatic stretching vibration. The absorption frequency at 2920 ~ 2851 cm ^-1 is assigned to aliphatic stretching vibration. The band at 1682 cm ^-1 is due to the presence of amide C=O stretching frequency. The absorption band at 1360 ~ 1236 cm ^-1 is consistent with C-N stretching vibration. The absorption band at 1565 cm ^-1 is due to C=C stretching vibration. In addition, compound 34 displayed characteristic absorption bands (cm ^-1 ) in the regions 761 ~ 693 (aromatic ring stretching) and 1112 (C-O-C ether linkage in the morpholine ring); this gives positive evidence for the formation of compound 34 . In the ¹ H NMR spectrum of 34 , a singlet observed at 3.91 ppm for two protons is assigned to methylene protons. The singlet for H-5 proton is observed at 6.69 ppm. The amide proton resonates at 10.25 ppm. Two triplets are observed and they are due to the methylene protons O(CH ₂ ) ₂ and N(CH ₂ ) ₂ of morpholine ring. Among the triplets, one triplet observed in the region of 2.65 ~ 2.63 ppm corresponding to two protons and this signal is due to methylene protons N(CH ₂ ) ₂ of morpholine ring. Another triplet appeared in the region of 3.49 ~ 3.47 ppm, corresponding to two protons, which can be conveniently assigned to methylene protons O(CH ₂ ) ₂ of morpholine ring. The aromatic protons resonate in the region 8.20 ~ 7.30 ppm. The ¹³ C resonance at 163.91 ppm is assigned to the amide group bearing carbon C-2 of pyrimidine moiety. The amide carbonyl carbon resonances at 169.40 ppm. The ¹³ C resonances observed at 164.72 and 101.27 ppm are due to the C-4 and C-5 carbons respectively. The ¹³ C resonances observed at 164.72 ppm is conveniently assigned to C-6 carbon. There are two ¹³ C resonances observed at 45.89 and 67.25 ppm. Among the two resonances, one ¹³ C resonance at 45.89 ppm is due to methylene carbon N(CH ₂ ) ₂ of morpholine ring and ¹³ C resonances at 67.25 ppm is unambiguously assigned to methylene carbon O(CH ₂ ) ₂ of morpholine ring. The methylene carbon attached to amide carbonyl carbon resonances at 66.23 ppm. The remaining ¹³ C signal at 137.38 ppm and 134.55 ppm are due to ipso carbons. The aromatic carbons are observed in the region of 130.30 ~ 126.87 ppm. The 1H and ¹³ C NMR chemical shifts of all the newly synthesized compounds are furnished in 3 and 4 respectively. In conclusion, we have synthesized a series of 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides 34 - 42 by a four step synthetic route in good yields and characterized by their physical and analytical data. The target molecules 34 - 42 have pharmacophoric group such as amide besides the presence of biologically active morpholine and pyrimidine nuclei. The biological screening studies are under progress to evaluate the antibacterial, antifungal, antioxidant and anticancer potencies of the newly synthesized of 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides 34 - 42 . Thin layer chromatography (TLC) was carried out to monitor the course of the reaction and purity of the product. All the reported melting points were taken in open capillaries and were uncorrected. IR spectra were recorded in KBr (pellet forms) on a Thermo Nicolet-Avatar-330 FT-IR spectrophotometer and important absorption values (cm ^-1 ) alone are listed. ¹ H and ¹³ C NMR spectra were recorded at 400 MHz and 100 MHz respectively on Bruker Avance II 400 NMR spectrometer using DMSO- d as solvent. The ESI +ve MS spectra were recorded on a Bruker Daltonics LC-MS spectrometer. Satisfactory microanalysis was obtained on Carlo Erba 1106 CHN analyzer. By adopting the literature precedent 1,3-diaryl-prop-2-en-1-ones 31 7 - 15 , 2-amino-4,6-diarylpyrimidines 32 16 - 24 and 2-chloro-N-(4,6-diarylpyrimidin-2-yl)acetamides 33 25 - 33 were synthesized. A mixture of 2-chloro-N-(4,6-diarylpyrimidin-2-yl)acetamides 25 - 33 (0.005 mol), anhydrous potassium carbonate (0.01 mol) and morpholine (0.005 mol) in dry toluene was refluxed for about 8 ~ 10 h. After completion of the reaction, potassium carbonate was removed by filtration and excess of solvent was removed under reduced pressure. The obtained residues were purified by column chromatography using benzene and ethylacetate (1:1) mixture as eluent which afforded 2-morpholino- N-(4,6-diarylpyrimidin-2-yl)acetamides 34 - 42 in good yields.