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Development of Diagnostic Strip for Determining Paraquat in Urine
Development of Diagnostic Strip for Determining Paraquat in Urine
Journal of the Korean Chemical Society. 2003. Aug, 47(4): 339-344
  • Published : August 20, 2003
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Park, Park Sang-Bum
Jang, Won-Cheoul
Kim, Jong-Wan

Abstract
Paraquat is an effective and widely used herbicide, but it is also very toxic to humans. It is well-known that urine paraquat concentration is one of the most important prognostic indicator for paraquat-poisoning. Quantitative analysis of paraquat, however, are not generally used in clinical laboratories. In this work, a new test strip to detect paraquat concentration using sodium dithionite in urine was developed. Using these second-derivative method, the test strip prepared in $0.5{\%}$ borate buffer (pH 8.0), 0.25 M $Na_2S_2O_4,\0.1~0.8{\%}$ PVP, and $1{\%}$ decanol showed not only better color reaction but also an excellent application possibility to be used in automatic analyzer.
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