This study has investigated the temperature-sensitive liposomes, which release anticancer drug(doxorubicin) at the hyperthermia temperature$(~40^{\circ}C)$. The temperature-sensitive liposomes were modified with a copolymers of N-isopropylacrylamide(NIPAAm) and acrylamide(AAm), which exhibit a lower critical solution temperature (LCST) at the hyperthermia temperature. The release of doxorubicin from the modified liposomes was determined by measuring the fluorescence intensity with changing temperature and time. The release of doxorubicin from liposomes modified with poly(NIPAAm-co-AAm) copolymer was increased significantly, because poly(NIPAAm-co-AAm) could undergo the conformational transition in the narrow hyperthermia temperature region$(~40{\pm}2^{\circ}C)$. Moreover, we observed that doxorubicin released from liposomes within 5 minutes, and the size of modified liposomes was 120~170 nm. In this study, we have prepared temperature-sensitive liposomes which could be controlled by temperature. They can be applied in the field of a drug delivery system for tumor targeting by temperature control.
@article{ JCGMDC_2003_v47n3_257}
,title={Temperature-sensitive Liposomes Modified with Poly(N-isopropylacrylamide-co-acrylamide)}
,volume={3}
, url={http://dx.doi.org/10.5012/jkcs.2003.47.3.257}, DOI={10.5012/jkcs.2003.47.3.257}
, number= {3}
, journal={Journal of the Korean Chemical Society}
, publisher={Korean Chemical Society}
, author={Hee Dong, Han
and
Sung Soo, Kim
and
Ho Suk, Choi
and
Byung Cheol, Shin}
, year={2003}
, month={Jun}
TY - JOUR
T2 - Journal of the Korean Chemical Society
AU - Hee Dong, Han
AU - Sung Soo, Kim
AU - Ho Suk, Choi
AU - Byung Cheol, Shin
SN - 1017-2548
TI - Temperature-sensitive Liposomes Modified with Poly(N-isopropylacrylamide-co-acrylamide)
VL - 47
PB - Korean Chemical Society
DO - 10.5012/jkcs.2003.47.3.257
PY - 2003
UR - http://dx.doi.org/10.5012/jkcs.2003.47.3.257
ER -
Hee Dong, H.
,
Sung Soo, K.
,
Ho Suk, C.
,
&
Byung Cheol, S.
( 2003).
Temperature-sensitive Liposomes Modified with Poly(N-isopropylacrylamide-co-acrylamide).
Journal of the Korean Chemical Society,
47
(3)
Korean Chemical Society.
doi:10.5012/jkcs.2003.47.3.257
Hee Dong, H
,
Sung Soo, K
,
Ho Suk, C
,
&
Byung Cheol, S
2003,
Temperature-sensitive Liposomes Modified with Poly(N-isopropylacrylamide-co-acrylamide),
Journal of the Korean Chemical Society,
vol. 3,
no. 3,
Retrieved from http://dx.doi.org/10.5012/jkcs.2003.47.3.257
[1]
H Hee Dong
,
K Sung Soo
,
C Ho Suk
,
and
S Byung Cheol
,
“Temperature-sensitive Liposomes Modified with Poly(N-isopropylacrylamide-co-acrylamide)”,
Journal of the Korean Chemical Society,
vol. 3,
no. 3,
Jun
2003.
Hee Dong, Han
Sung Soo, Kim
Ho Suk, Choi
et al.
“Temperature-sensitive Liposomes Modified with Poly(N-isopropylacrylamide-co-acrylamide)”
Journal of the Korean Chemical Society,
3.
3
2003:
Hee Dong, H
,
Sung Soo, K
,
Ho Suk, C
,
Byung Cheol, S
Temperature-sensitive Liposomes Modified with Poly(N-isopropylacrylamide-co-acrylamide).
Journal of the Korean Chemical Society
[Internet].
2003.
Jun ;
3
(3)
Available from http://dx.doi.org/10.5012/jkcs.2003.47.3.257
Hee Dong, Han
,
Sung Soo, Kim
,
Ho Suk, Choi
,
and
Byung Cheol, Shin
,
“Temperature-sensitive Liposomes Modified with Poly(N-isopropylacrylamide-co-acrylamide).”
Journal of the Korean Chemical Society
3
no.3
()
Jun,
2003):
http://dx.doi.org/10.5012/jkcs.2003.47.3.257