Temperature-sensitive Liposomes Modified with Poly(N-isopropylacrylamide-co-acrylamide)

This study has investigated the temperature-sensitive liposomes, which release anticancer drug(doxorubicin) at the hyperthermia temperature$(~40^{\circ}C)$. The temperature-sensitive liposomes were modified with a copolymers of N-isopropylacrylamide(NIPAAm) and acrylamide(AAm), which exhibit a lower critical solution temperature (LCST) at the hyperthermia temperature. The release of doxorubicin from the modified liposomes was determined by measuring the fluorescence intensity with changing temperature and time. The release of doxorubicin from liposomes modified with poly(NIPAAm-co-AAm) copolymer was increased significantly, because poly(NIPAAm-co-AAm) could undergo the conformational transition in the narrow hyperthermia temperature region$(~40{\pm}2^{\circ}C)$. Moreover, we observed that doxorubicin released from liposomes within 5 minutes, and the size of modified liposomes was 120~170 nm. In this study, we have prepared temperature-sensitive liposomes which could be controlled by temperature. They can be applied in the field of a drug delivery system for tumor targeting by temperature control.

Keywords

Hyperthermia ; Tumor Targeting ; Liposomes ; Temperature-Sensitive Polymer

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@article{ JCGMDC_2003_v47n3_257} ,title={Temperature-sensitive Liposomes Modified with Poly(N-isopropylacrylamide-co-acrylamide)} ,volume={3} , url={http://dx.doi.org/10.5012/jkcs.2003.47.3.257}, DOI={10.5012/jkcs.2003.47.3.257} , number= {3} , journal={Journal of the Korean Chemical Society} , publisher={Korean Chemical Society} , author={Hee Dong, Han and Sung Soo, Kim and Ho Suk, Choi and Byung Cheol, Shin} , year={2003} , month={Jun}