Fucoidan is a kind of polysaccharides in brown seaweeds. For the past years have been extensively studied due to their numerous biological activities : anticancer, anticoagulant, antithrombotic, anti-inflammatory and antiviral. In this study, we h ave extracted fucoidan from the Korean brown seaweeds and examined it's anticancer activities for employed SV40 DNA replication assay, RPA-ssDNA binding assay of replication protein A(RPA: known as human single-stranded DNA-binding protein essential for DNA rep-lication) and MCF7 cell growth inhibition assay. In addition to, we found that chemically sulfated fucoidan'santicancer activity is more higher than natural and desulfated fucoidan. It seem that fucoidan's sulfate group affect on DNA replication, cause of decrease RPA's DNA binding activity. These results suggests that sulfated fucoidan from Korean brown seaweeds have anticancer activity.
@article{ JCGMDC_2002_v46n2_151}
,title={Increased Anticancer Activity by the Surfated Funcoidan from Korean Brown Seaweeds}
,volume={2}
, url={http://dx.doi.org/10.5012/jkcs.2002.46.2.151}, DOI={10.5012/jkcs.2002.46.2.151}
, number= {2}
, journal={Journal of the Korean Chemical Society}
, publisher={Korean Chemical Society}
, author={Jang-Su, Park
and
An Deu Re, Kim
and
Eun-Hui, Kim
and
Hong-Suk, Seo
and
Won-Cheol, Choe}
, year={2002}
, month={Apr}
TY - JOUR
T2 - Journal of the Korean Chemical Society
AU - Jang-Su, Park
AU - An Deu Re, Kim
AU - Eun-Hui, Kim
AU - Hong-Suk, Seo
AU - Won-Cheol, Choe
SN - 1017-2548
TI - Increased Anticancer Activity by the Surfated Funcoidan from Korean Brown Seaweeds
VL - 46
PB - Korean Chemical Society
DO - 10.5012/jkcs.2002.46.2.151
PY - 2002
UR - http://dx.doi.org/10.5012/jkcs.2002.46.2.151
ER -
Jang-Su, P.
,
An Deu Re, K.
,
Eun-Hui, K.
,
Hong-Suk, S.
,
&
Won-Cheol, C.
( 2002).
Increased Anticancer Activity by the Surfated Funcoidan from Korean Brown Seaweeds.
Journal of the Korean Chemical Society,
46
(2)
Korean Chemical Society.
doi:10.5012/jkcs.2002.46.2.151
Jang-Su, P
et al.
2002,
Increased Anticancer Activity by the Surfated Funcoidan from Korean Brown Seaweeds,
Journal of the Korean Chemical Society,
vol. 2,
no. 2,
Retrieved from http://dx.doi.org/10.5012/jkcs.2002.46.2.151
[1]
P Jang-Su
,
K An Deu Re
,
K Eun-Hui
,
S Hong-Suk
,
and
C Won-Cheol
,
“Increased Anticancer Activity by the Surfated Funcoidan from Korean Brown Seaweeds”,
Journal of the Korean Chemical Society,
vol. 2,
no. 2,
Apr
2002.
Jang-Su, Park
An Deu Re, Kim
Eun-Hui, Kim
et al.
“Increased Anticancer Activity by the Surfated Funcoidan from Korean Brown Seaweeds”
Journal of the Korean Chemical Society,
2.
2
2002:
Jang-Su, P
,
An Deu Re, K
,
Eun-Hui, K
,
Hong-Suk, S
,
Won-Cheol, C
Increased Anticancer Activity by the Surfated Funcoidan from Korean Brown Seaweeds.
Journal of the Korean Chemical Society
[Internet].
2002.
Apr ;
2
(2)
Available from http://dx.doi.org/10.5012/jkcs.2002.46.2.151
Jang-Su, Park
,
An Deu Re, Kim
,
Eun-Hui, Kim
,
Hong-Suk, Seo
,
and
Won-Cheol, Choe
,
“Increased Anticancer Activity by the Surfated Funcoidan from Korean Brown Seaweeds.”
Journal of the Korean Chemical Society
2
no.2
()
Apr,
2002):
http://dx.doi.org/10.5012/jkcs.2002.46.2.151