One-pot Mannich reaction of substituted hydroxy aromatic compounds with secondary amines in an aprotic solvent has been studied. The results demonstrate that the relative reactivity and regioselectivity of the Mannich reaction depend on the steric hindrance of amines as well as the nucleophilicity of hydroxy aromatic rings.
Citing 'Synthesis of Mannich Bases Using Substitued Aromatic Alcohols with Secondary Amines: Relative Reactivity and Regioselectivity Depending on Substrates
'
@article{ JCGMDC_2001_v45n1_51}
,title={Synthesis of Mannich Bases Using Substitued Aromatic Alcohols with Secondary Amines: Relative Reactivity and Regioselectivity Depending on Substrates}
,volume={1}
, number= {1}
, journal={Journal of the Korean Chemical Society}
, publisher={Korean Chemical Society}
, author={Ki Whan, Chi
and
Yoon Soo, Ahn
and
Tae Ho, Park
and
Jeong Soo, Ahn
and
Hyun Ah, Kim
and
Joo Yeon, Park}
, year={2001}
, month={Feb}
TY - JOUR
T2 - Journal of the Korean Chemical Society
AU - Ki Whan, Chi
AU - Yoon Soo, Ahn
AU - Tae Ho, Park
AU - Jeong Soo, Ahn
AU - Hyun Ah, Kim
AU - Joo Yeon, Park
SN - 1017-2548
TI - Synthesis of Mannich Bases Using Substitued Aromatic Alcohols with Secondary Amines: Relative Reactivity and Regioselectivity Depending on Substrates
VL - 45
PB - Korean Chemical Society
PY - 2001
ER -
Ki Whan, C.
,
Yoon Soo, A.
,
Tae Ho, P.
,
Jeong Soo, A.
,
Hyun Ah, K.
,
&
Joo Yeon, P.
( 2001).
Synthesis of Mannich Bases Using Substitued Aromatic Alcohols with Secondary Amines: Relative Reactivity and Regioselectivity Depending on Substrates.
Journal of the Korean Chemical Society,
45
(1)
Korean Chemical Society.
Ki Whan, C
et al.
2001,
Synthesis of Mannich Bases Using Substitued Aromatic Alcohols with Secondary Amines: Relative Reactivity and Regioselectivity Depending on Substrates,
Journal of the Korean Chemical Society,
vol. 1,
no. 1,
[1]
C Ki Whan
,
A Yoon Soo
,
P Tae Ho
,
A Jeong Soo
,
K Hyun Ah
,
and
P Joo Yeon
,
“Synthesis of Mannich Bases Using Substitued Aromatic Alcohols with Secondary Amines: Relative Reactivity and Regioselectivity Depending on Substrates”,
Journal of the Korean Chemical Society,
vol. 1,
no. 1,
Feb
2001.
Ki Whan, Chi
Yoon Soo, Ahn
Tae Ho, Park
et al.
“Synthesis of Mannich Bases Using Substitued Aromatic Alcohols with Secondary Amines: Relative Reactivity and Regioselectivity Depending on Substrates”
Journal of the Korean Chemical Society,
1.
1
2001:
Ki Whan, C
,
Yoon Soo, A
,
Tae Ho, P
,
Jeong Soo, A
,
Hyun Ah, K
,
Joo Yeon, P
Synthesis of Mannich Bases Using Substitued Aromatic Alcohols with Secondary Amines: Relative Reactivity and Regioselectivity Depending on Substrates.
Journal of the Korean Chemical Society
[Internet].
2001.
Feb ;
1
(1)
Ki Whan, Chi
,
Yoon Soo, Ahn
,
Tae Ho, Park
,
Jeong Soo, Ahn
,
Hyun Ah, Kim
,
and
Joo Yeon, Park
,
“Synthesis of Mannich Bases Using Substitued Aromatic Alcohols with Secondary Amines: Relative Reactivity and Regioselectivity Depending on Substrates.”
Journal of the Korean Chemical Society
1
no.1
()
Feb,
2001):
