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Synthesis of Mannich Bases Using Substitued Aromatic Alcohols with Secondary Amines: Relative Reactivity and Regioselectivity Depending on Substrates
Synthesis of Mannich Bases Using Substitued Aromatic Alcohols with Secondary Amines: Relative Reactivity and Regioselectivity Depending on Substrates
Journal of the Korean Chemical Society. 2001. Feb, 45(1): 51-60
  • Published : February 00, 2001
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Chi, Ki Whan
Ahn, Yoon Soo
Park, Tae Ho
Ahn, Jeong Soo
Kim, Hyun Ah
Park, Joo Yeon

Abstract
One-pot Mannich reaction of substituted hydroxy aromatic compounds with secondary amines in an aprotic solvent has been studied. The results demonstrate that the relative reactivity and regioselectivity of the Mannich reaction depend on the steric hindrance of amines as well as the nucleophilicity of hydroxy aromatic rings.