The binding mode of anthryl derivatives to synthetic polynucleotides were investigated by various spectroscopic methods. The spectroscopic properties of anthracence with metbylamine and methylethylenediamine side chains, complexed with $poly[d(A-T)_2]$ and $poly[d(G-C)_2]$, can be summarized as a red-shift, with a strong hypochromism in the absortion spectrum, similar induced CD spectra, and a strong negative LD spectrum with an $LD^r$ magnitude comparable to the DNA absorption region. These observations indicate that anthracene moiety is intercalated between the nucleo-bases of $poly[d(A-T)_2]$ and $poly[d(G-C)_2]$. The side chains did not alter the spectroscopic properties, demonstrating that the binding mode was not affected by them. A strong energy transfer was observed from poly[d(A-T),] and $poly[d(I-C)_2]$ but not from $poly[d(G-C)_2]$, as reported by Kumar et al. (J. Am. Chem. Soc.(1993) 115, 8547). Since the binding mode is the same for all the polynucleotides, the amine group of the guanine base, which protrudes into the minor groove of $poly[d(G-C)_2]$, is concluded to disrupt the energy transfer.
Citing 'Binding Properties of Anthryl Derivatives to Synthetic Polynucleotide and the Role of Guanine Amine Group in the Energy Transfer
'
@article{ JCGMDC_2000_v44n1_45}
,title={Binding Properties of Anthryl Derivatives to Synthetic Polynucleotide and the Role of Guanine Amine Group in the Energy Transfer}
,volume={1}
, number= {1}
, journal={Journal of the Korean Chemical Society}
, publisher={Korean Chemical Society}
, author={Chang-Beom, Cho
and
Gwan-Su, Son
and
Sung-Wook, Han
and
Maeng-Jun, Jung
and
Hyun-Suk, Chong
and
Gil-Jun, Lee}
, year={2000}
, month={Feb}
TY - JOUR
T2 - Journal of the Korean Chemical Society
AU - Chang-Beom, Cho
AU - Gwan-Su, Son
AU - Sung-Wook, Han
AU - Maeng-Jun, Jung
AU - Hyun-Suk, Chong
AU - Gil-Jun, Lee
SN - 1017-2548
TI - Binding Properties of Anthryl Derivatives to Synthetic Polynucleotide and the Role of Guanine Amine Group in the Energy Transfer
VL - 44
PB - Korean Chemical Society
PY - 2000
ER -
Chang-Beom, C.
,
Gwan-Su, S.
,
Sung-Wook, H.
,
Maeng-Jun, J.
,
Hyun-Suk, C.
,
&
Gil-Jun, L.
( 2000).
Binding Properties of Anthryl Derivatives to Synthetic Polynucleotide and the Role of Guanine Amine Group in the Energy Transfer.
Journal of the Korean Chemical Society,
44
(1)
Korean Chemical Society.
Chang-Beom, C
et al.
2000,
Binding Properties of Anthryl Derivatives to Synthetic Polynucleotide and the Role of Guanine Amine Group in the Energy Transfer,
Journal of the Korean Chemical Society,
vol. 1,
no. 1,
[1]
C Chang-Beom
,
S Gwan-Su
,
H Sung-Wook
,
J Maeng-Jun
,
C Hyun-Suk
,
and
L Gil-Jun
,
“Binding Properties of Anthryl Derivatives to Synthetic Polynucleotide and the Role of Guanine Amine Group in the Energy Transfer”,
Journal of the Korean Chemical Society,
vol. 1,
no. 1,
Feb
2000.
Chang-Beom, Cho
Gwan-Su, Son
Sung-Wook, Han
et al.
“Binding Properties of Anthryl Derivatives to Synthetic Polynucleotide and the Role of Guanine Amine Group in the Energy Transfer”
Journal of the Korean Chemical Society,
1.
1
2000:
Chang-Beom, C
,
Gwan-Su, S
,
Sung-Wook, H
,
Maeng-Jun, J
,
Hyun-Suk, C
,
Gil-Jun, L
Binding Properties of Anthryl Derivatives to Synthetic Polynucleotide and the Role of Guanine Amine Group in the Energy Transfer.
Journal of the Korean Chemical Society
[Internet].
2000.
Feb ;
1
(1)
Chang-Beom, Cho
,
Gwan-Su, Son
,
Sung-Wook, Han
,
Maeng-Jun, Jung
,
Hyun-Suk, Chong
,
and
Gil-Jun, Lee
,
“Binding Properties of Anthryl Derivatives to Synthetic Polynucleotide and the Role of Guanine Amine Group in the Energy Transfer.”
Journal of the Korean Chemical Society
1
no.1
()
Feb,
2000):