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Protonation State of Norfloxacin and Their Interaction with DNA
Protonation State of Norfloxacin and Their Interaction with DNA
Yeo, Jeong-Ah;Son, Gwan-Su;Kim, Jong-Moon;Moon, Hyung-Rang;Jun, Eun-Duk;Cho, Tae-Sub
Journal of the Korean Chemical Society. 2000. Feb, 44(1): 4-9
DOI : http://dx.doi.org/
  • Published : February 20, 2000
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Yeo, Jeong-Ah
Son, Gwan-Su
Kim, Jong-Moon
Moon, Hyung-Rang
Jun, Eun-Duk
Cho, Tae-Sub
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Yeo, Jeong-Ah
Son, Gwan-Su
Kim, Jong-Moon
Moon, Hyung-Rang
Jun, Eun-Duk
Cho, Tae-Sub
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Abstract
We investigated the self-association and protonation state of norfloxacin, a member of quinokme antibiotics, using electric absorption and potentiom,etric titration. Both nitrogen at the piperazine ring and carboxylic acid were protonated at a low pH (cationic norfloxacin), and deprotonated at a high pH (anionic norfloxacin). In the intermediate pH range, a neutral species was dominant with the possibility of forming a zwitter ion. We also observed that nortloxacin molecules can be sracked to form a dimer at an intermediate pH, The equilibrium constant of the norfloxacin-DNA complex formation, which was measured by Stem-Volmermethod, increases as the pH of the system is lowered. This observation indicates that it is the cationic nortloxacin that forms a complex with DNA among various norfloxacin species in aqueous solution.
Citing 'Protonation State of Norfloxacin and Their Interaction with DNA '
@article{ JCGMDC_2000_v44n1_4} ,title={Protonation State of Norfloxacin and Their Interaction with DNA} ,volume={1} , number= {1} , journal={Journal of the Korean Chemical Society} , publisher={Korean Chemical Society} , author={Jeong-Ah, Yeo and Gwan-Su, Son and Jong-Moon, Kim and Hyung-Rang, Moon and Eun-Duk, Jun and Tae-Sub, Cho} , year={2000} , month={Feb}