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Synthesis and Antimicrobial Activity of Polymethacryloylsulfadiazine
Synthesis and Antimicrobial Activity of Polymethacryloylsulfadiazine
Journal of the Korean Chemical Society. 1995. Sep, 39(9): 749-754
  • Published : September 00, 1995
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Kim, Sun-Il
Na, Jae-Woon
Yun, Young-Jae
Choi, kyong-Rai

Abstract
The synthetic procedures to synthesize polymethacryloylsulfadiazine were searched by DCC method and Acid Chloride mothod. Polymeric drug was synthesized by Acid Chloride method in high yield (72%) but DCC method in low yield (23%). The antimicrobial activities of polymeric drug were investigated in terms of minimum inhibitory concentrations by the common two-fold dilution technique. Polymeric drug revealed an excellent antimicrobial Bacillus subtillis ATCC 6633, Mycrobacterium phlei IFO 3158, Micrococus luteus ATCC 9341, Salmonella typhimurium KCTC 1925, Klebsiella pneumoniae KCTC 1560 and similar activity against Staphylococcus aureus IFO 12732, Escherichia coli BE 1186, Escherichia coli AB 0111, Pseudomonas aeruginosa IFO 13130. Polymeric drug have no antimicrobial activity against Candida albicans IFO 1594.