Advanced
Deracemization of Racemic Amino Acids Using (R)- and (S)-Alanine Racemase Chiral Analogues as Chiral Converters
Deracemization of Racemic Amino Acids Using (R)- and (S)-Alanine Racemase Chiral Analogues as Chiral Converters
Bulletin of the Korean Chemical Society. 2014. Jul, 35(7): 2186-2188
Copyright © 2014, Korea Chemical Society
  • Received : March 10, 2014
  • Accepted : March 19, 2014
  • Published : July 20, 2014
Download
PDF
e-PUB
PubReader
PPT
Export by style
Article
Author
Metrics
Cited by
TagCloud
About the Authors
Man-Jeong Paik
College of Pharmacy, Sunchon National University, Suncheon, Jeonnam 540-950, Korea
So Hee Jeon
Jong Seong Kang
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea
Kwan Mook Kim
Department of Chemistr/Division of Nano Sciences, Ewha Womans University, Seoul 120-750, Korea
Wonjae Lee

Abstract
Keywords
PPT Slide
Lager Image
PPT Slide
Lager Image
PPT Slide
Lager Image
PPT Slide
Lager Image
PPT Slide
Lager Image
Experimental
The chemicals used in this study were purchased from Aldrich (Milwaukee, WI) or Fluka (Switzerland) and were analytical-reagent grade. ( R )- and ( S )-ARCA were provided by Aminologics Company (Sungnam, Korea). The amino acid stereoconversion samples using ( R )- and ( S )-ARCA were prepared as described previously. 2-5 HPLC studies were carried out using a Breeze system (Waters, Milford, MA) equipped with a binary pump (Waters model 1525), an autosampler, and a dual absorbance detector (Waters 2487 detector). Capcell Pak C18 UG 120 (250 × 4.6 mm I.D., 5 μm) (Shiseido Company, Japan) for diastereomer analysis and ChiroSil SCA (250 × 4.6 mm I.D., 5 μm) (RS Tech, Daejon, Korea) based on (−)-18-C-6-TA for enantiomer analysis were used. 10,11
References
Turner N. J. 2004 Curr. Opin. Chem. Biol. 8 114 -    DOI : 10.1016/j.cbpa.2004.02.001
Park, H.-J., Nandhakumar R. , Hong J. , Ham S. , Chin J. , Kim K. M. 2008 Chem. Eur. J. 14 9935 -    DOI : 10.1002/chem.200801036
Nandhakumar R. , Ryu J. , Park H.-J. , Tang L. , Choi S. , Kim K. M. 2008 Tetrahedron 64 7704 -    DOI : 10.1016/j.tet.2008.06.029
Tang L. , Ga H. , Kim J. , Choi S. , Nandhakumar R. , Kim K. M. 2008 Tetrahedron Lett. 49 6914 -    DOI : 10.1016/j.tetlet.2008.09.117
Park H.-J. , Kim K. M. , Lee A. , Ham S. , Nam W. , Chin J. 2007 J. Am. Chem. Soc. 129 1518 -    DOI : 10.1021/ja067724g
Subramanian, G. 2001 Chiral Separation Techniques: A Practical Approach Wiley-VCH Weinheim
Eliel E. L. , Wilen S. H. , Mandor L. N. 1994 Stereochemistry of Organic Compounds John Wiley & Sons New York
Bang E. , Jin J. Y. , Hong J. H. , Kang J. S. , Lee W. , Lee W. 2012 Bull. Korean Chem. Soc. 33 3481 -    DOI : 10.5012/bkcs.2012.33.10.3481
Lee W. , Bang E. , Lee W. 2003 Chromatographia 57 457 -    DOI : 10.1007/BF02492541
Paik M.-J. , Kang J. S. , Huang B.-S. , Carey J. R. , Lee W. 2013 J. Chromatogr. A 1274 1 -    DOI : 10.1016/j.chroma.2012.11.086
Jin J. Y. , Lee W. , Hyun M. H. 2006 J. Liq. Chrom. & Rel. Technol. 29 841 -    DOI : 10.1080/10826070500531102