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Ingacamerounol, A New Flavonol and Other Chemical Constituents from Leaves and Stem Bark of Inga edulis Mart.
Ingacamerounol, A New Flavonol and Other Chemical Constituents from Leaves and Stem Bark of Inga edulis Mart.
Bulletin of the Korean Chemical Society. 2013. Dec, 34(12): 3859-3862
Copyright © 2013, Korea Chemical Society
  • Received : July 03, 2013
  • Accepted : September 09, 2013
  • Published : December 20, 2013
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About the Authors
Aimee M. T. Tchuenmogne
Department of Organic Chemistry, Faculty of Science, TWAS Research Unit (TRU) of the University of Yaounde I, P.O. Box 812 Yaounde, Cameroon
Erik V. Donfack
Institute of Organic and Biomolecular Chemistry, Georg-August University, Tammannstr.2, D-37077 Gottingen, Germany
Michel D. T. Kongue
Institute of Organic and Biomolecular Chemistry, Georg-August University, Tammannstr.2, D-37077 Gottingen, Germany
Bruno N. Lenta
Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, P.O. Box 47 Yaounde, Cameroon
Silvere Ngouela
Department of Organic Chemistry, Faculty of Science, TWAS Research Unit (TRU) of the University of Yaounde I, P.O. Box 812 Yaounde, Cameroon
Etienne Tsamo
Department of Organic Chemistry, Faculty of Science, TWAS Research Unit (TRU) of the University of Yaounde I, P.O. Box 812 Yaounde, Cameroon
Navdeep Sidhu
Department of Structural Chemistry, University of Gottingen, Tammannstr. 4, 37077 Gottingen, Germany
Birger Dittrich
Department of Structural Chemistry, University of Gottingen, Tammannstr. 4, 37077 Gottingen, Germany
Hartmut Laatsch
Institute of Organic and Biomolecular Chemistry, Georg-August University, Tammannstr.2, D-37077 Gottingen, Germany

Abstract
Keywords
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Experimental Section
General. UV/Vis spectra were recorded in neutral, acidic (HCl), and basic (NaOH) MeOH on a Varian CARY (3E) UV/Vis spectrophotometer. The CD spectrum was recorded on a Jasco J-810 spectropolarimeter. The optical rotation was recorded in MeOH on a Jasco P-2000 polarimeter. IR spectra were recorded on a Jasco FT/IR-4100 Fourier-transform infrared spectrometer type A. The 1 H NMR spectra were recorded on Varian Mercury-300 (300.141 MHz), Varian VNMRS-300 (300.536 MHz), Varian Inova-500 (499.8 MHz) and Inova-600 (599.744 MHz) spectrometers equipped with 3 mm probes; 13 C NMR spectra were measured at 125.707 MHz and 150.821 MHz relatively to TMS as internal standard; shifts are reported as δ values. Electrospray-ionization mass spectrometry (ESIMS) and high-resolution mass spectra (HRESIMS) were recorded on a micrOTOF time-of-flight mass spectrometer (Bruker Daltonics, Bremen/Germany), as well as on an Apex IV7 Tesla Fourier-transform ion cyclotron resonance mass spectrometer (Bruker Daltonics, Billerica, MA/USA). Flash and column chromatography (CC): silica gels (SiO 2 ; 230- 400 and 70-230 mesh; Merck). Pre-coated silica gel 60 F 254 aluminum sheets were used for TLC with different mixtures of n -hexane, ethyl acetate, dichloromethane and methanol as eluents; spots were detected using UV lamps (254 and 365 nm) or by spraying with 50% H 2 SO 4 followed by heating at 50-100 ℃.
Plant Material. The stem bark and leaves of I . edulis were collected in January 2010 at Mbalmayo in the Centre Region of the Republic of Cameroon. The plant was identified by Mr. V. Nana, botanist at the National Herbarium (Yaounde, Cameroon), where a voucher specimen (no. 65644 HNC) has been deposited.
Ingacamerounol (1): Yellow powder; molecular formula C 17 H 12 O 8 ;
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0° ( c 0.25, MeOH); UV/Vis (MeOH): λ max (log ε) 218 (4.34), 261 (4.27), 297 (3.86) and 363 (4.22) nm. - UV/Vis (HCl): λ max (log ε) 216 (4.38), 261 (4.28), 298 (3.88) and 363 (4.22) nm. - UV/Vis (NaOH): λ max (log ε) 221 (4.44), 273 (4.38), 323 (3.92) and 408 (4.36) nm; IR λ max 3339, 3081, 1648, 1612, 1557, 1030 cm -1 ; 1 H NMR (300 MHz, DMSO- d 6 ) and 13 C NMR (125 MHz, DMSO- d 6 ) data, see Table 1 ; MS ((+)-ESI) m/z : 367.1 [M+Na] + , 711.1 [2M+Na] + , 1055.2 [3M+Na] + , 1399.3 [4M+Na] + . - MS ((-)- ESI) m/z : 343.0 [M-H] - , 687.1 [2M-H] - , 1031.1 [3M-H] - . - HRMS((+)-ESI) m/z : 367.0423 (calcd. 367.0424 for C 17 H 12 NaO 8 , [M+Na] + ) and HRMS ((-)-ESI) m/z :343.0458 (calcd. 343.0459 for C 17 H 11 O 8 , [M-H] - ).
Acknowledgements
Suporting Information.Details on isolation,1H and13C NMR spectra, X-ray data of compound1together with the biological activities are available as Supporting Information. And the publication cost of this paper was supported by the Korean Chemical Society.
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