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Effects of Jowiseungcheongtang water extract on Cultured Primary Hippocampal Cell Culture Damaged by XO/HX
Effects of Jowiseungcheongtang water extract on Cultured Primary Hippocampal Cell Culture Damaged by XO/HX
Journal of Sasang Constitutional Medicine. 2002. Apr, 14(1): 67-78
  • Published : April 30, 2002
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Kim, Hyoung-Soon
Kim, Kyung-Yo
Go, Gi-Deok
Kim, Il-Hwan
Song, Seung-Yun

Abstract
Jowiseungcheongtang(JST) has been in Sasang constitution medicine for many years as a therapeutic agent for cerebral disease. But the effect of Jowiseungcheongtang(JST) on neurotoxicity is not known. The purpose of this study was to determine the effects of Jowiseungcheongtang(JST) on the hippocampal cell injured by Xanthine Oxidase/Hypoxanthine. The results were as follows: 1. XO/HX decreased the survival rate of the cultured hippocampal cells on NR assay and MTT assay. 2. JST water extract have efficacy of decreasing a amount of lipid peroxidation increased by XO/HX in cultured hippocampal cells. 3. JST water extract have efficacy of increasing DNA synthesis decreased by XO/HX in cultured hippocampal cells. From the above results, It is concluded that JST has marked efficacy in preventing cultured hippocampal cells from the damages by XO/HX.
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