Mechanosensitive β-catenin signaling regulates lymphatic vascular development
Mechanosensitive β-catenin signaling regulates lymphatic vascular development
BMB Reports. 2016. Aug, 49(8): 403-404
Copyright © 2016, Korean Society for Biochemistry and Molecular Biology
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  • Received : July 14, 2016
  • Published : August 31, 2016
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Boksik, Cha
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation
R. Sathish, Srinivasan
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA

The Wnt/β-catenin signaling is an evolutionarily conserved pathway that plays a pivotal role in embryonic development and adult homeostasis. However, we have limited information about the involvement of Wnt/β-catenin signaling in the lymphatic vascular system that regulates fluid homeostasis by absorbing interstitial fluid and returning it to blood circulation. In this recent publication we report that canonical Wnt/β-catenin signaling is highly active and critical for the formation of lymphovenus valves (LVVs) and lymphatic valves (LVs). β-catenin directly associates with the regulatory elements of the lymphedema-associated transcription factor, FOXC2 and activates its expression in an oscillatory shear stress (OSS)-dependent manner. The phenotype of β-catenin null embryos was rescued by FOXC2 overexpression. These results suggest that Wnt/β-catenin signaling is a mechanotransducer that links fluid force with lymphatic vascular development. [BMB Reports 2016; 49(8): 403-404]
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RSS is supported by NIH/NHLBI (R01HL131652), institutional funds of OMRF, Oklahoma Center for Adult Stem Cell Research (OCASCR, 4340) and American Heart Association (15BGIA25710032). BC is supported by a post-doctoral fellowship from American Heart Association (15POST25080182).