Advanced
Dopamine-dependent synaptic plasticity in an amygdala inhibitory circuit controls fear memory expression
Dopamine-dependent synaptic plasticity in an amygdala inhibitory circuit controls fear memory expression
BMB Reports. 2016. Feb, 49(1): 1-2
Copyright © 2016, Korean Society for Biochemistry and Molecular Biology
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • Received : December 14, 2015
  • Published : February 29, 2016
Download
PDF
e-PUB
PubReader
PPT
Export by style
Share
Article
Author
Metrics
Cited by
TagCloud
About the Authors
Joo Han Lee
Joung-Hun Kim
joungkim@postech.ac.kr

Abstract
Of the numerous events that occur in daily life, we readily remember salient information, but do not retain most less-salient events for a prolonged period. Although some of the episodes contain putatively emotional aspects, the information with lower saliency is rarely stored in neural circuits via an unknown mechanism. We provided substantial evidence indicating that synaptic plasticity in the dorsal ITC of amygdala allows for selective storage of salient emotional experiences, while it deters less-salient experience from entering long-term memory. After activation of D4R or weak fear conditioning, STDP stimulation induces LTD in the LA-ITC synapses. This form of LTD is dependent upon presynaptic D4R, and is likely to result from enhancement of GABA release. Both optogenetic abrogation of LTD and ablation of D4R at the dorsal ITC in vivo lead to heightened and over-generalized fear responses. Finally, we demonstrated that LTD was impaired at the dorsal ITC of PTSD model mice, which suggests that maladaptation of GABAergic signaling and the resultant LTD impairment contribute to the endophenotypes of PTSD. [BMB Reports 2016; 49(1): 1-2]
Keywords
PPT Slide
Lager Image
Acknowledgements
This work was supported by grants from the National Research Foundation of Korea (2015R1A2A1A15054037, 2015M3C7A-1027351 &2014R1A2A2A01002921) to J.-H.K.
References