Advanced
Role of neuropeptide Y in the bone marrow hematopoietic stem cell microenvironment
Role of neuropeptide Y in the bone marrow hematopoietic stem cell microenvironment
BMB Reports. 2015. Dec, 48(12): 645-646
Copyright © 2015, Korean Society for Biochemistry and Molecular Biology
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • Received : November 02, 2015
  • Published : December 31, 2015
Download
PDF
e-PUB
PubReader
PPT
Export by style
Share
Article
Author
Metrics
Cited by
About the Authors
Min Hee Park
Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University
Woo-Kie Min
Department of Orthopaedic Surgery, Kyungpook National University Hospital, Daegu 41944, Korea
Hee Kyung Jin
Department of Laboratory Animal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea
Jae-sung Bae
Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University
jsbae@knu.ac.kr

Abstract
The sympathetic nervous system (SNS) or neurotransmitters in the bone marrow microenvironment has been known to regulate hematopoietic stem cell (HSC) functions such as self-renewal, proliferation and differentiation. However, the specific role of neuropeptide Y (NPY) in this process remains relatively unexplored. In this study, we demonstrated that NPY deficient mice have significantly reduced HSC numbers and impaired bone marrow regeneration due to apoptotic destruction of SNS fibers and/or endothelial cells. Moreover, NPY treatment prevented bone marrow impairments in a mouse model of chemotherapy-induced SNS injury, while conditional knockout mice lacking the Y1 receptor in macrophages did not restore bone marrow dysfunction in spite of NPY injection. Transforming growth factor-beta (TGF-β) secreted by NPY-mediated Y1 receptor stimulation in macrophages plays a key role in neuroprotection and HSC survival in the bone marrow. Therefore, this study reveals a new role of NPY in bone marrow HSC microenvironment, and provides an insight into the therapeutic application of this neuropeptide. [BMB Reports 2015; 48(12): 645-646]
Keywords
PPT Slide
Lager Image
Acknowledgements
This work was supported by Biomedical Research Institute grant, Kyungpook National University Hospital (2012).
References