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Inhibition of Monoamine Oxidase by Anithiactins from Streptomyces sp.
Inhibition of Monoamine Oxidase by Anithiactins from Streptomyces sp.
Journal of Microbiology and Biotechnology. 2015. Sep, 25(9): 1425-1428
Copyright © 2015, The Korean Society For Microbiology And Biotechnology
  • Received : May 08, 2015
  • Accepted : May 27, 2015
  • Published : September 28, 2015
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About the Authors
Hyun Woo Lee
Department of Pharmacy, Sunchon National University, Suncheon 540-950, Republic of Korea
Won Kyeong Jung
Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 540-950, Republic of Korea
Hee Jung Kim
Department of Pharmacy, Sunchon National University, Suncheon 540-950, Republic of Korea
Yu Seok Jeong
Department of Pharmacy, Sunchon National University, Suncheon 540-950, Republic of Korea
Sang-Jip Nam
Department of Chemistry and Nano Science, Ewha Women’s University, Seoul 120-750, Republic of Korea
Heonjoong Kang
Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Republic of Korea
Hoon Kim
Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 540-950, Republic of Korea
hoon@sunchon.ac.kr

Abstract
Monoamine oxidase (MAO) is found in most cell types and catalyzes the oxidation of monoamines. Three anithiactins (A-C, modified 2-phenylthiazoles) isolated from Streptomyces sp. were tested for inhibitory activity of two isoforms, MAO-A and MAO-B. Anithiactin A was effective and selective for the inhibition of MAO-A, with an IC 50 value of 13.0 μM; however, it was not effective for the inhibition of MAO-B. Anithiactins B and C were weaker inhibitors for MAO-A and MAO-B. Anithiactin A was a reversible and competitive inhibitor for MAO-A with a K i value of 1.84 μM. The hydrophobic methyl substituent in anithiactin A may play an important role in the inhibition of MAO-A. It is suggested that anithiactin A is a selective reversible inhibitor for MAO-A, with moderate potency, and can be considered a new potential lead compound for further development of novel reversible inhibitors for MAO-A.
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Acknowledgements
This study was supported by the Suncheon Research Center for Natural Medicines, Republic of Korea.
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