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Anti-Mycobacterial Activity of Tamoxifen Against Drug-Resistant and Intra-Macrophage Mycobacterium tuberculosis
Anti-Mycobacterial Activity of Tamoxifen Against Drug-Resistant and Intra-Macrophage Mycobacterium tuberculosis
Journal of Microbiology and Biotechnology. 2015. Jun, 25(6): 946-950
Copyright © 2015, The Korean Society For Microbiology And Biotechnology
  • Received : December 10, 2014
  • Accepted : January 22, 2015
  • Published : June 28, 2015
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About the Authors
Woong Sik Jang
Regional Innovation Center, Soonchunhyang University, Asan 336-745, Republic of Korea
Sukyung Kim
Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan 330-090, Republic of Korea
Biswajit Podder
Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan 330-090, Republic of Korea
Md. Anirban Jyoti
Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan 330-090, Republic of Korea
Kung-Woo Nam
Departments of Life Science and Biotechnology
Byung-Eui Lee
Chemistry, Soonchunhyang University, Asan 336-745, Republic of Korea
Ho-Yeon Song
Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan 330-090, Republic of Korea
songmic@sch.ac.kr

Abstract
Recently, it has become a struggle to treat tuberculosis with the current commercial antituberculosis drugs because of the increasing emergence of multidrug-resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis . We evaluated here the antimycobacterial activity of tamoxifen, known as a synthetic anti-estrogen, against eight drugsensitive or resistant strains of Mycobacterium tuberculosis (TB), and the active intracellular killing of tamoxifen on TB in macrophages. The results showed that tamoxifen had antituberculosis activity against drug-sensitive strains (MIC, 3.125-6.25 µg/ml) as well as drugresistant strains (MIC, 6.25 to 12.5 µg/ml). In addition, tamoxifen profoundly decreased the number of intracellular TB in macrophages in a dose-dependent manner.
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Acknowledgements
This work was supported by a grant from the Ministry of Health & Welfare R&D Project, Republic of Korea (HI13C0828).
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