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Lactobacillus rhamnosus GG Reverses Insulin Resistance but Does Not Block Its Onset in Diet-Induced Obese Mice
Lactobacillus rhamnosus GG Reverses Insulin Resistance but Does Not Block Its Onset in Diet-Induced Obese Mice
Journal of Microbiology and Biotechnology. 2015. May, 25(5): 753-757
Copyright © 2015, The Korean Society For Microbiology And Biotechnology
  • Received : September 05, 2014
  • Accepted : November 25, 2014
  • Published : May 28, 2015
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About the Authors
Kun-Young Park
Bobae Kim
Chang-Kee Hyun
ckhyun@handong.edu

Abstract
Recently, Lactobacillus rhamnosus GG (LGG) was shown to exert insulin-sensitizing and adiposity-reducing effects in high-fat (HF) diet-fed mice. In the present study, we observed that the effects were correlated with the extent of dysbiosis induced by HF diet feeding before LGG administration. LGG-treated mice were protected from HF diet-induced adiposity and/or insulin resistance when LGG was treated after, not along with, HF diet feeding. Results indicate that, under HF dietary condition, supplemented LGG reverses insulin resistance, but does not block its onset.
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Acknowledgements
This work was supported by the National Research Foundation Grant funded by the Korean Government (MEST, 2012R1A1B6003789).
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