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Whitening Effect of Octaphlorethol A Isolated from Ishige foliacea in an In Vivo Zebrafish Model
Whitening Effect of Octaphlorethol A Isolated from Ishige foliacea in an In Vivo Zebrafish Model
Journal of Microbiology and Biotechnology. 2015. Apr, 25(4): 448-451
Copyright © 2015, The Korean Society For Microbiology And Biotechnology
  • Received : September 12, 2014
  • Accepted : October 22, 2014
  • Published : April 28, 2015
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About the Authors
Kil-Nam Kim
Jeju Center, Korea Basic Science Institute (KBSI), Jeju 690-140, Republic of Korea
Hye-Mi Yang
Department of Marine Life Science, Jeju National University, Jeju 690-756, Republic of Korea
Sung-Myung Kang
Department of Marine Life Science, Jeju National University, Jeju 690-756, Republic of Korea
Ginnae Ahn
Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu 550-749, Republic of Korea
Seong Woon Roh
Jeju Center, Korea Basic Science Institute (KBSI), Jeju 690-140, Republic of Korea
WonWoo Lee
Department of Marine Life Science, Jeju National University, Jeju 690-756, Republic of Korea
Daekyung Kim
Jeju Center, Korea Basic Science Institute (KBSI), Jeju 690-140, Republic of Korea
dkim@kbsi.re.kr
You-Jin Jeon
Department of Marine Life Science, Jeju National University, Jeju 690-756, Republic of Korea
dkim@kbsi.re.kr

Abstract
In a previous study, we isolated octaphlorethol A (OPA) from Ishige foliacea and evaluated its anti-melanogenesis activity in a murine melanoma cell line. However, the whitening effect and toxicity of OPA have not yet been examined in vivo . Therefore, in this study, we investigated the inhibitory effect of OPA on melanin synthesis and tyrosinase activity in an in vivo zebrafish model. More than 90% of subject embryos survived upon exposure to OPA concentrations below 25 µM, which was not significantly different from the finding in the control group. OPA markedly inhibited melanin synthesis and tyrosinase activity in a concentration-dependent manner.
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Acknowledgements
This research was supported by Ministry of Agriculture, Food and Rural Affairs (MAFRA), Ministry of Oceans and Fisheries (MOF), Rural Development Administration (RDA) and Korea Forest Service (KFS) (213004-04-2-SB930). This research was financially supported by the Ministry of Education (MOE) and National Research Foundation of Korea (NRF) through the Human Resource Training Project for Regional Innovation (NRF-2012H1B8A2025863).
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