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Tracking Study About Adenovirus 36 Infection: Increase of Adiposity
Tracking Study About Adenovirus 36 Infection: Increase of Adiposity
Journal of Microbiology and Biotechnology. 2015. Dec, 25(12): 2169-2172
Copyright © 2015, The Korean Society For Microbiology And Biotechnology
  • Received : September 02, 2015
  • Accepted : September 25, 2015
  • Published : December 28, 2015
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About the Authors
Sooho Park
Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of Korea
Jihye Kim
Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea
Hye-Jung Shin
Department of Pediatrics, National Medical Center, Seoul 04564, Republic of Korea
Young Mi Hong
Department of Pediatrics, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul 07985, Republic of Korea
Youn Ho Sheen
Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul 06135, Republic of Korea
Hye-Lim Park
Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of Korea
Hyun-Jung Jeon
Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of Korea
Sun-Young Ahn
Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of Korea
Jae-Hwan Nam
Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Republic of Korea
jhnam@catholic.ac.kr

Abstract
This study investigated the cross-sectional and longitudinal association between adenovirus 36 (Ad36) and obesity in 79 Korean adolescent boys over 1 year. We analyzed the changes in body composition and metabolic risk factors according to the presence of Ad36 antibodies. Ad36 antibodies in serum were detected using the constant virus-decreasing serum method. We found that the fat percentage and fasting insulin in the Ad36-seropositive group were greater than the Ad36-seronegative group. These results suggest that Ad36 infection is associated with an increase of adiposity, and the experience of Ad36 infection may affect the future fat gain of adolescents.
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Antibody prevalence against Ad36 represented by Ad36 (-) or Ad36 (+). * p < 0.05.
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Acknowledgements
This work was supported by the Basic Science Research Program of the National Research Foundation of Korea (2012R1A1A2039819 and 2015M3A9B5030116), and the Korean Health Technology R&D Project, Ministry of Health & Welfare (HI13C0826). We thank Dr. Ha-Na Na for excellent guidance in the serum-neutralizing assay.
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