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A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis
A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis
Journal of Microbiology and Biotechnology. 2015. Nov, 25(11): 1966-1969
Copyright © 2015, The Korean Society For Microbiology And Biotechnology
  • Received : June 29, 2015
  • Accepted : August 11, 2015
  • Published : November 28, 2015
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About the Authors
Hyejin Kim
Haemaru Referral Animal Hospital, Sungnam 463-050, Republic of Korea
Irfan A. Rather
Department of Applied Microbiology and Biotechnology, Yeungnam University, Gyeongsan 712-749, Republic of Korea
Hyunwook Kim
Haemaru Referral Animal Hospital, Sungnam 463-050, Republic of Korea
Sungsoo Kim
Haemaru Referral Animal Hospital, Sungnam 463-050, Republic of Korea
Taeeun Kim
Haemaru Referral Animal Hospital, Sungnam 463-050, Republic of Korea
Jaeyoung Jang
Haemaru Referral Animal Hospital, Sungnam 463-050, Republic of Korea
Jimin Seo
Haemaru Referral Animal Hospital, Sungnam 463-050, Republic of Korea
Jeongheui Lim
National Science Museum Ministry of Science, ICT and Future Planning, Daejeon 305-705, Republic of Korea
Yong-Ha Park
proBionic, Yusung, Daejeon 305-333, Republic of Korea
peter@ynu.ac.kr

Abstract
Canine atopic dermatitis (CAD) is a ubiquitous, chronic inflammatory skin disorder prevalent in dogs, which results in production of abnormal levels of IgE antibodies in reciprocation to an allergen challenge. In this study, administration of the probiotic strain Lactobacillus sakei probio-65 for 2 months significantly reduced the disease severity index in experimental dogs diagnosed with CAD. In addition, one month pre-medication of L. sakei probio-65 revealed significant difference in the PVAS score in experimental dogs for both probio-65 and placebo groups. However, post 2 months treatment resulted in a significant decrease in the CASESI score values in the probio-65-treated group ( p < .0.06).
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Acknowledgements
This study was supported by the National Research Foundation of Korea (2013M3A9A5047052, 2008-2004707 and 2012-0006701).
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