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In Vitro Virucidal Effect of Mouthrinse Containing C31G on Seasonal Influenza Viruses
In Vitro Virucidal Effect of Mouthrinse Containing C31G on Seasonal Influenza Viruses
Journal of Microbiology and Biotechnology. 2014. Jul, 24(7): 921-924
Copyright © 2014, The Korean Society For Microbiology And Biotechnology
  • Received : December 20, 2013
  • Accepted : March 24, 2014
  • Published : July 30, 2014
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About the Authors
Dong-Hun Lee
College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea
Ha-Na Youn
College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea
Jae-Keun Park
College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea
Byung-Hwa Kang
Research Laboratories, Ildong Pharmaceutical Co., Ltd., Hwaseong 445-170, Republic of Korea
Jae-Hoon Kang
Research Laboratories, Ildong Pharmaceutical Co., Ltd., Hwaseong 445-170, Republic of Korea
Joong-Bok Lee
College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea
Seung-Yong Park
College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea
In-Soo Choi
College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea
Sang-Won Lee
College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea
Chang-Seon Song
College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea
songcs@konkuk.ac.kr

Abstract
C31G is a potent antimicrobial agent and can disrupt the microbial membrane by the alkyl portion of the molecule. The objective of this study was to evaluate the virucidal effectiveness of C31G and mouthrinse containing C31G (Sense-Time) on seasonal influenza viruses. Evaluation of the virucidal activity against influenza viruses was performed with end-point titration in 10-day-old chicken embryos and Madin-Darby canine kidney cells. In vitro studies demonstrated that C31G and Sense-Time inhibited the growth of seasonal influenza viruses even in the presence of 5% organic material. Gargling with C31G or Sense-Time would enhance oropharyngeal hygiene, which would be helpful for reducing influenza transmission.
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Acknowledgements
This work was supported by the KU Research Professor Program of Konkuk University.
References
CDC 2009 Infection Control Guidance for the Prevention and Control of Influenza in Acute-Care Facilities. Centers for Disease Control and Prevention Atlanta, GA, USA.
Corner AM , Dolan MM , Yankell SL , Malamud D 1988 C31G, a new agent for oral use with potent antimicrobial and antiadherence properties. Antimicrob. Agents Chemother. 32 350 - 353    DOI : 10.1128/AAC.32.3.350
Feldblum PJ , Adeiga A , Bakare R , Wevill S , Lendvay A , Obadaki F 2008 SAVVY vaginal gel (C31G) for prevention of HIV infection: a randomized controlled trial in Nigeria. PLoS One 3 e1474 -    DOI : 10.1371/journal.pone.0001474
Iwata M , Toda M , Nakayama M , Tsujiyama H , Endo W , Takahashi O 1997 Prophylactic effect of black tea extract as gargle against influenza. Kansenshogaku Zasshi 71 487 - 494
Loeb L 2005 Beating the flu: orthodox and commercial responses to influenza in Britain, 1889-1919. Soc. Hist. Med. 18 203 - 224    DOI : 10.1093/sochis/hki030
Lorenz RJ , Bogel K 1973 Laboratory techniques in rabies: methods of calculation. Monogr. Ser. World Health Organ. 321 - 335
Meiller TF , Silva A , Ferreira SM , Jabra-Rizk MA , Kelley JI , DePaola LG 2005 Efficacy of Listerine antiseptic in reducing viral contamination of saliva. J. Clin. Periodontol. 32 341 - 346    DOI : 10.1111/j.1600-051X.2005.00673.x
Michaels EB , Hahn EC , Kenyon AJ 1983 Effect of C31G, an antimicrobial surfactant, on healing of incised guinea pig wounds. Am. J. Vet. Res. 44 1378 - 1381
Sakai M , Shimbo T , Omata K , Takahashi Y , Satomura K , Kitamura T 2008 Cost-effectiveness of gargling for the prevention of upper respiratory tract infections. BMC Health Serv. Res. 8 258 -    DOI : 10.1186/1472-6963-8-258
Sholapurkar AA , Pai KM , Rao S 2009 Comparison of efficacy of fluconazole mouthrinse and clotrimazole mouthpaint in the treatment of oral candidiasis. Aust. Dent. J. 54 341 - 346    DOI : 10.1111/j.1834-7819.2009.01160.x
WHO 2010 Pandemic (H1N1) 2009 - update 112. World Health Organization. Accessible at .