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Lycorine: A Potential Broad-Spectrum Agent Against Crop Pathogenic Fungi
Lycorine: A Potential Broad-Spectrum Agent Against Crop Pathogenic Fungi
Journal of Microbiology and Biotechnology. 2014. Mar, 24(3): 354-358
Copyright © 2014, The Korean Society For Microbiology And Biotechnology
  • Received : October 17, 2013
  • Accepted : December 13, 2013
  • Published : March 30, 2014
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About the Authors
Jin-Wen Shen
College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China
Yuan Ruan
College of Agronomy, Henan Agricultural University, Zhengzhou 450002, China
Wei Ren
College of Agronomy, Henan Agricultural University, Zhengzhou 450002, China
Bing-Ji Ma
College of Agronomy, Henan Agricultural University, Zhengzhou 450002, China
mbj123@sina.com
Xiao-Long Wang
College of Agronomy, Henan Agricultural University, Zhengzhou 450002, China
Chun-Feng Zheng
College of Agronomy, Henan Agricultural University, Zhengzhou 450002, China

Abstract
A screening test showed that lycorine exhibited significant antifungal activity against 24 pathogenic crop fungi at concentrations of 500 μg/ml and 100 μg/ml, respectively. Fusarium graminearum was selected for antifungal mechanism studies by observing its mycelial morphology and investigating the variations in its conductivity. In addition, the substance absorption and metabolism of F. graminearum were explored. The mechanism was revealed as being one by which lycorine destroyed the cellular membrane and further influenced substance absorption and cell metabolism.
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Acknowledgements
This work was supported by special funds for the construction of modern agricultural technology systems in China. None of the authors have any conflicts of interests to declare.
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