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Biofilm Formation and Antibiotic Resistance in Salmonella Typhimurium Are Affected by Different RibonucleasesS
Biofilm Formation and Antibiotic Resistance in Salmonella Typhimurium Are Affected by Different RibonucleasesS
Journal of Microbiology and Biotechnology. 2014. Jan, 24(1): 8-12
Copyright © 2014, The Korean Society For Microbiology And Biotechnology
  • Accepted : October 11, 2013
  • Published : January 30, 2014
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About the Authors
Margarida Saramago
Susana Domingues
Sandra Cristina Viegas
Cecília Maria Arraiano
cecilia@itqb.unl.pt

Abstract
Biofilm formation and antibiotic resistance are important determinants for bacterial pathogenicity. Ribonucleases control RNA degradation and there is increasing evidence that they have an important role in virulence mechanisms. In this report, we show that ribonucleases affect susceptibility against ribosome-targeting antibiotics and biofilm formation in Salmonella .
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Acknowledgements
We acknowledge Andreia Aires for technical assistance. Fundação para a Ciência e Tecnologia (FCT- Portugal) gave financial support to M. Saramago (PhD fellowship), S. Domingues (Postdoctoral fellowship), and S.C. Viegas (Postdoctoral Fellowship). This work was supported by grants from Fundação para a Ciência e a Tecnologia (FCT)-Portugal (including grants Pest-OE/EQB/LA0004/2011, PTDC/BIQ/111757/2009, PTDC/BIA-MIC/4142/2012) and a grant from the European Commission FP7-KBBE-2011-1-289326.
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