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Lactobacillus plantarum HY7712 Protects Against the Impairment of NK-Cell Activity Caused by Whole-Body γ-Irradiation in Mice
Lactobacillus plantarum HY7712 Protects Against the Impairment of NK-Cell Activity Caused by Whole-Body γ-Irradiation in Mice
Journal of Microbiology and Biotechnology. 2014. Jan, 24(1): 127-131
Copyright © 2014, The Korean Society For Microbiology And Biotechnology
  • Received : July 08, 2013
  • Accepted : October 07, 2013
  • Published : January 30, 2014
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About the Authors
Hoyong Lee
Korea Yakult Co., Ltd., Yongin 449-901, Republic of Korea
Young-Tae Ahn
Korea Yakult Co., Ltd., Yongin 449-901, Republic of Korea
Se-Hoon Park
Korea Yakult Co., Ltd., Yongin 449-901, Republic of Korea
Do-Young Park
Korea Yakult Co., Ltd., Yongin 449-901, Republic of Korea
Young-Woo Jin
Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro and Nuclear Power Co., Ltd., Seoul 132-703, Republic of Korea
Cha Soon Kim
Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro and Nuclear Power Co., Ltd., Seoul 132-703, Republic of Korea
Sang Hyun Sung
College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea
Chul-Sung Huh
Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Seoul 151-742, Republic of Korea
Dong-Hyun Kim
College of Pharmacy, Kyung Hee University, Seoul 130-702, Republic of Korea
dhkim@khu.ac.kr

Abstract
While searching for lactic acid bacteria that can restore aging-impaired immune responses, we isolated the Toll-like receptor (TLR) 2/NF-κB-activating strain Lactobacillus plantarum HY7712 from kimchi and investigated its immunomodulating effect in whole-body γ-irradiated mice. Exposure to HY7712 strongly activated NF-κB signaling in RAW264.7 cells, but inhibited lipopolysaccharide-stimulated NF-κB activation. Moreover, HY7712 protected against the downregulation of interferon (IFN)-γ and upregulation of interleukin (IL)-13 caused by γ-irradiation in mice. In mice, γ-irradiation impaired NK-cell activity against YAC-1 tumor cells, but following HY7712 exposure, the activity of NK cells was restored to 91.5% of the level measured in control mice ( p < 0.05). These findings suggest that HY7712 activates the TLR2/NF-κB signaling pathway and protects against the impairment of NK-cell activity caused by γ-irradiation or aging.
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