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Lactobacillus brevis G101 Inhibits the Absorption of Monosodium Glutamate in Mice
Lactobacillus brevis G101 Inhibits the Absorption of Monosodium Glutamate in Mice
Journal of Microbiology and Biotechnology. 2014. Nov, 24(11): 1592-1596
Copyright © 2014, The Korean Society For Microbiology And Biotechnology
  • Received : February 27, 2014
  • Accepted : July 17, 2014
  • Published : November 28, 2014
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About the Authors
Se-Eun Jang
Department of Food and Nutrition, Kyung Hee University, Seoul 130-701, Republic of Korea
Myung Joo Han
Department of Food and Nutrition, Kyung Hee University, Seoul 130-701, Republic of Korea
Se-Young Kim
R & D Center, CTCBIO Inc., Gyeonggi-do 445-913, Republic of Korea
Dong-Hyun Kim
Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea
dhkim@khu.ac.kr

Abstract
To evaluate the effect of Lactobacillus brevis G-101 on absorption of monosodium glutamate (MSG), we orally administered MSG with or without G-101 in mice and measured the maximum concentration (Cmax) and blood concentration curve (AUC) of MSG and γ-aminobutyric acid (GABA). Oral administration of G-101 (1 × 10 9 CFU/mouse) potently inhibited Cmax and AUC of MSG by 97.8% and 94.3%, respectively ( p < 0.05), but increased those of GABA by 32.1% and 67.7%, respectively ( p < 0.05). G-101 inhibited the absorption of MSG. These results suggest that G-101 may reduce the side effect of MSG by inhibiting the absorption of MSG.
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References
Campieri M , Gionchetti P 1999 Probiotics in inflammatory bowel disease: new insight to pathogenesis or a possible therapeutic alternative. Gastroenterology 116 1246 - 1260    DOI : 10.1016/S0016-5085(99)70029-6
Cherubini E , Gaiarsa JL , Ben-Ari Y 1991 GABA: an excitatory transmitter in early postnatal life. Trends Neurosci. 14 515 - 519    DOI : 10.1016/0166-2236(91)90003-D
Cho YR , Chang JY , Chang HC 2007 Production of gammaaminobutyric acid (GABA) byLactobacillus buchneriisolated from kimchi and its neuroprotective effect on neuronal cells. J. Microbiol. Biotechnol. 17 104 - 109
Jang SE , Hyam SR , Han MJ , Kim SY , Lee BG , Kim DH 2013 Lactobacillus brevisG-101 ameliorates colitis in mice by inhibiting NF-κB, MAPK and AKT pathways and by polarizing M1 macrophages to M2-like macrophages. J. Appl. Microbiol. 115 888 - 896    DOI : 10.1111/jam.12273
Jung IH , Jung MA , Kim EJ , Han MJ , Kim DH 2012 Lactobacillus pentosusvar.plantarumC29 protects scopolamineinduced memory deficit in mice. J. Appl. Microbiol. 113 1498 - 1506    DOI : 10.1111/j.1365-2672.2012.05437.x
Kanmani P , Satish Kumar R , Yuvaraj N , Paari KA , Pattukumar V , Arul V 2013 Probiotics and its functionally valuable products - a review. Crit. Rev. Food Sci. Nutr. 53 641 - 658    DOI : 10.1080/10408398.2011.553752
Kumari A , Catanzaro R , Marotta F 2011 Clinical importance of lactic acid bacteria: a short review. Acta Bio-med. 82 177 - 180
Lee JH , Lee B , Lee HS , Bae EA , Lee H , Ahn YT 2009 Lactobacillus suntoryeusinhibits pro-inflammatory cytokine expression and TLR-4-linked NF-kappaB activation in experimental colitis. Int. J. Colorect. Dis. 24 231 - 237    DOI : 10.1007/s00384-008-0618-6
Morselli PL , Garattini S 1970 Monosodium glutamate and the Chinese restaurant syndrome. Nature 227 611 - 612    DOI : 10.1038/227611a0
Perdigon G , de Jorrat WEB , de Petrino SF , Valerde de Budeguer M 1991 Effect of oral administration ofLactobacillus caseion various biological functions of the host. Food Agric. Immunol. 3 93 - 102    DOI : 10.1080/09540109109354735
Schaumburg HH , Byck R , Gerstl R , Mashman JH 1969 Monosodium L-glutamate: its pharmacology and role in the Chinese restaurant syndrome. Science 163 826 - 828    DOI : 10.1126/science.163.3869.826
Schaumburg H 1986 Chinese-restaurant syndrome. New Engl. J. Med. 278 1122 -
Scopp AL 1991 MSG and hydrolyzed vegetable protein induced headache: review and case studies. Headache 31 107 - 110    DOI : 10.1111/j.1526-4610.1991.hed3102107.x
Shimada A , Cairns BE , Vad N , Ulriksen K , Pedersen AM , Svensson P , Baad-Hansen L 2013 Headache and mechanical sensitization of human pericranial muscles after repeated intake of monosodium glutamate (MSG). J. Headache Pain 14 2 -    DOI : 10.1186/1129-2377-14-2
Tabuchi M , Ozaki M , Tamura A , Yamada N , Ishida T , Hosoda M , Hosono A 2003 Antidiabetic effect ofLactobacillusGG in streptozotocin-induced diabetic rats. Biosci. Biotechnol. Biochem. 67 1421 - 1424    DOI : 10.1271/bbb.67.1421
Tamura T , Noda M , Ozaki M , Maruyama M , Matoba Y , Kumagai T , Sugiyama M 2010 Establishment of an efficient fermentation system of gamma-aminobutyric acid by a lactic acid bacterium,Enterococcus aviumG-15, isolated from carrot leaves. Biol. Pharm. Bull. 33 1673 - 1679    DOI : 10.1248/bpb.33.1673
Tung YT , Lee BH , Liu CF , Pan TM 2011 Optimization of culture condition for ACEI and GABA production by lactic acid bacteria. J. Food Sci. 76 M585 - M591    DOI : 10.1111/j.1750-3841.2011.02379.x
Xiong JS , Branigan D , Li M 2009 Deciphering the MSG controversy. Int. J. Clin. Exp. Med. 2 329 - 336
Yang WH , Drouin MA , Herbert M , Mao Y , Karsh J 1997 The monosodium glutamate symptom complex: assessment in a double-blind, placebo-controlled, randomized study. J. Allergy Clin. Immunol. 99 757 - 762    DOI : 10.1016/S0091-6749(97)80008-5
Zhang Y , Song L , Gao Q , Yu SM , Li L , Gao NF 2012 The two-step biotransformation of monosodium glutamate to GABA byLactobacillus brevisgrowing and resting cells. Appl. Microbiol. Biotechnol. 94 1619 - 1627    DOI : 10.1007/s00253-012-3868-8