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Effect of Orally Administered Lactobacillus brevis HY7401 in a Food Allergy Mouse Model
Effect of Orally Administered Lactobacillus brevis HY7401 in a Food Allergy Mouse Model
Journal of Microbiology and Biotechnology. 2013. Nov, 23(11): 1636-1640
Copyright © 2013, The Korean Society For Microbiology And Biotechnology
  • Received : June 19, 2013
  • Accepted : August 27, 2013
  • Published : November 30, 2013
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About the Authors
Jeongmin Lee
Division of Zoonoses, Center for Immunology and Pathology, National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongwon-gun, Chungcheongbuk-do, 363-951, Republic of Korea
Jieun Bang
Laboratory of Immunology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea
Hee-Jong Woo Woo
Laboratory of Immunology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea
hjwoo@snu.ac.kr

Abstract
We had found that orally administered Lactobacillus species were effective immune modulators in ovalbumin (OVA)-sensitized mice. To validate these findings, we investigated the effects of orally administered Lactobacillus brevis HY7401 n OVA-T cell receptor transgenic mice. This strain showed a tendency to induce Th1 cytokines and inhibit Th2 cytokines. All assayed isotypes of OVA-specific antibody were effectively reduced. Systemic anaphylaxis was also relatively reduced with the probiotic administration. These results reveal that L. brevis HY7401 might be useful to promote anti-allergic processes through oral administration.
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Acknowledgements
This work was supported by a research grant from Korea Yakult Co., Ltd to H.-J. W. None of the authors have any conflicts of interest to declare.
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